Nutrition
NUTRITION AND VITILIGO
NUTRITION AND VITILIGO
Nutrition
NUTRITION AND VITILIGO
There is a desperate longing in the majority of people with vitiligo for a cure, or for some way of alleviating the symptoms. This leads them to grasp at anything that might carry some hope. At times when the vitiligo is actively spreading people feel particularly helpless. Anything that would bring back a feeling of control may be tried.
Food, of course, is one area where it feels possible to bring some control to our lives. Manipulating the diet is sometimes helpful in treating some conditions like eczema. However, dramatic changes in the diet can cause other problems if not done with some knowledge or advice. For instance, in some cultures it has been suggested (without evidence) that avoiding white foods can lead to an improvement in vitiligo. This involves avoiding dairy foods which are a good source of calcium, particularly important for young children who need it to develop strong bones and teeth.
The body is a complex mechanism, made up of millions of cells and regulated by complex hormones and enzyme systems. A wide range of nutrients are needed to maintain this in a healthy functioning state. Not only are nutrients needed, but they themselves interact, inhibit, compete or rely on one another for effective functioning. This is why picking out one vitamin or mineral alone either as a cause of a problem or to take as a supplement is not usually helpful.
There are several vitamins and minerals involved in the production of melanin and enzymes involved in the process of pigmentation. Interest has focused especially on these as possibly having some effect on the course of vitiligo. If it was as simple as finding one malfunctioning nutrient, we would have had a cure long ago. Because vitiligo can improve spontaneously, it has sometimes been assumed that when this is happening it is due to something else e.g. treatment for another condition or a change of diet. This has led to reports, without a sound scientific basis, that certain nutrients can cure vitiligo. It has also led to more research into trying to understand how certain nutrients are involved in skin pigmentation. Such studies so far have been difficult to conduct, usually have small numbers of participants, and are mostly not very reliable. They can, however, help to build up our overall understanding of the connection between diet and vitiligo
Vitamin B12 and folic Acid
In patients with pernicious anaemia, vitamin B12 is not available to the body because the substance in the stomach needed for its absorption is not present. Pernicious anaemia is one of the auto-immune diseases associated with vitiligo. There have been occasional reports, in cases where both diseases exist in the same patient, that when the pernicious anaemia is treated by injections of vitamin B12 the vitiligo also improves. Montes noted in his studies of his patients with vitiligo that 10.7% had low levels of vitamin B12 in their blood. This work was done in Argentina where the diet is very different from UK. (Montes LF,Vitiligo, Nutritional Therapy; Westhoven Press .
Montes LF Vitiligo: Current Knowledge and Nutritional Therapy (2nd ed) Westhoven Press, Buenos Aires 2006
Folic acid contains substances which play a role in the pigmentation process. Vitamin B12 and folic acid work closely together. Both are needed to facilitate some biological processes and have been investigated, together, in research projects. One small study (15 participants in all) giving these two nutrients with vitamin C showed some re-pigmentation in half the patients (Montes et al. Cutis 1992; 50:39 - 42). A more recent randomised trial, (Tjioe et al. Acta Derm Venereol 2002; 82:369-372)of 28 patients treated with narrow band UVB for a year showed no added benefit of adding supplementary vitamin B12 and folic acid to the treatment. Another study (Julin L, Olsson MJ. Acta DermVenereol 1997;77;50:39-42) using these two vitamins with solar UV exposure showed an improvement, but the UV exposure was not standardised and there was no control group.
Para amino benzoic acid (PABA)
This is one of the components of folic acid which probably accounts for its apparent effect on vitiligo. It is an ingredient of some sunscreens as it can block some UV light. Although it has been reported to promote repigmentation, this is only in combination with other B complex vitamins. It has been reported to cause vitiligo in one case. (J Am. Academ Dermatol. 1983; 9:770}
Phenylalanine
Phenylalanine is an essential amino acid which is found in a normal diet. It may increase the body's tolerance to UVA. There are a few reports of some improvements in patients having UVA treatment when phenylalanine is added. This has improved outcomes and it is suggested that this warrants more investigation. ( Szczurko O. and Boon HS. A Systematic Review of Natural Health product treatment for vitiligo. BMC Dermatology 2008 8:2 – online publication)
Beta carotene
This is a precursor of vitamin A. In large doses it is deposited in the skin giving it a yellow tint. Some people have used this to colour the very white patches of vitiligo. It does not remain in the skin, so would need to be taken continuously to maintain the colour. In normal amounts in food it has a protective effect against damage by free radicals. Free radicals are toxic waste products produced as a result of a biochemical process in the body. They cause damage to tissue cells and are believed to be implicated in many chronic diseases.
Vitamin D
Vitamin D is only found in a few foods such as oily fish, cod liver oil, liver, milk, eggs and foods such as margarine, some milk powders and yogurts and some cereals are fortified with it in the UK. It is vital for bone health and can help to maintain a healthy immune system. About 90% of the requirement of vitamin D is synthesised by the body from the effect of UVB rays on the skin. There has been concern that in people with vitiligo continuous use of sunblock may prevent the body producing the vitamin itself. Most of the vitamin D is formed during the summer and only a small amount of exposure (15 – 20 minutes a day two or three times a week) will provide sufficient as well as body stores for the winter months when sunlight levels are lower. It is best to spread the exposure over the week. There is some debate about how much sun vitiligo patients should have as some is thought to be beneficial (Ref Dispatches No 32 page 8 July 2003)
Minerals
Copper, iron, zinc and calcium all have a role in the pigmentation process. Low levels of zinc and copper have been linked with premature greying hair. Low levels of both minerals have also been found in de-pigmented skin. Iron is also low in de-pigmented skin and has a role in the activation of tyrosinase. Tyrosinase is a copper requiring enzyme and is essential in the pigmentation process.
Antioxidants
Recent research has shown the importance of preventing tissue damage by free radicals. It is thought that a good supply of antioxidant nutrients can improve the immune system function and help prevent chronic diseases, such as heart disease and some cancers. Antioxidants neutralise these free radicals and protect against the damage. This is increasingly seen as an important factor in vitiligo too. The main antioxidant nutrients are vitamins A. C. E. carotene and folic acid, polyphenolic flavanoids and some minerals such as selenium, copper and zinc. Though selenium levels in the British diet have fallen in recent years a study showed that blood levels in vitiligo patients were not low. A recent randomised controlled trial (Dell’Anna et al. Clinical and Experimental Dearmatology, 32,631-636) showed that giving antioxidants with narrowband UVB improved the effectiveness of the light treatment.
Curcumin, (Turmeric)
In the diet has been shown to be reduce the effectiveness of treatment of vitiligo with pseudocatalase in a small study of asian patients who have a significant amount of turmeric in their diet.(Schallreuter K. Rokos.H. Indian J. Dermatol, Venreol, Leprol 72: 57-59)
Summary
It is clear that there is no simple nutritional answer to vitiligo. However, as a good supply of nutrients is required both to promote a healthy skin and in the pigmentation process, a good, varied diet is important.
The best way to ensure adequate amounts of these nutrients is by having as much variety as possible in the diet including plenty of fruit and vegetables (at least five servings per day). A variety of starchy foods as a basis for each meal and smaller servings of fat rich and highly processed foods is recommended. It is better to try and increase the nutrient rich foods in the diet than rely on too many supplements. Although supplements can have a place sometimes, there may still be unknown beneficial factors available in foods that are not provided by nutrients in tablet form.
广大白癜风，治愈或减轻症状的方法，对一些人有一种绝望的向往。这使得他们抓住任何可能进行了一些希望。白癜风是积极传播时的时间，让人感到特别无奈。可尝试任何会带回一种控制的感觉。There is a desperate longing in the majority of people with vitiligo for a cure, or for some way of alleviating the symptoms. This leads them to grasp at anything that might carry some hope. At times when the vitiligo is actively spreading people feel particularly helpless. Anything that would bring back a feeling of control may be tried.
Food, of course, is one area where it feels possible to bring some control to our lives. Manipulating the diet is sometimes helpful in treating some conditions like eczema. However, dramatic changes in the diet can cause other problems if not done with some knowledge or advice. For instance, in some cultures it has been suggested (without evidence) that avoiding white foods can lead to an improvement in vitiligo. This involves avoiding dairy foods which are a good source of calcium, particularly important for young children who need it to develop strong bones and teeth.
The body is a complex mechanism, made up of millions of cells and regulated by complex hormones and enzyme systems. A wide range of nutrients are needed to maintain this in a healthy functioning state. Not only are nutrients needed, but they themselves interact, inhibit, compete or rely on one another for effective functioning. This is why picking out one vitamin or mineral alone either as a cause of a problem or to take as a supplement is not usually helpful.
There are several vitamins and minerals involved in the production of melanin and enzymes involved in the process of pigmentation. Interest has focused especially on these as possibly having some effect on the course of vitiligo. If it was as simple as finding one malfunctioning nutrient, we would have had a cure long ago. Because vitiligo can improve spontaneously, it has sometimes been assumed that when this is happening it is due to something else e.g. treatment for another condition or a change of diet. This has led to reports, without a sound scientific basis, that certain nutrients can cure vitiligo. It has also led to more research into trying to understand how certain nutrients are involved in skin pigmentation. Such studies so far have been difficult to conduct, usually have small numbers of participants, and are mostly not very reliable. They can, however, help to build up our overall understanding of the connection between diet and vitiligo
Vitamin B12 and folic Acid
In patients with pernicious anaemia, vitamin B12 is not available to the body because the substance in the stomach needed for its absorption is not present. Pernicious anaemia is one of the auto-immune diseases associated with vitiligo. There have been occasional reports, in cases where both diseases exist in the same patient, that when the pernicious anaemia is treated by injections of vitamin B12 the vitiligo also improves. Montes noted in his studies of his patients with vitiligo that 10.7% had low levels of vitamin B12 in their blood. This work was done in Argentina where the diet is very different from UK. (Montes LF,Vitiligo, Nutritional Therapy; Westhoven Press .
Montes LF Vitiligo: Current Knowledge and Nutritional Therapy (2nd ed) Westhoven Press, Buenos Aires 2006
Folic acid contains substances which play a role in the pigmentation process. Vitamin B12 and folic acid work closely together. Both are needed to facilitate some biological processes and have been investigated, together, in research projects. One small study (15 participants in all) giving these two nutrients with vitamin C showed some re-pigmentation in half the patients (Montes et al. Cutis 1992; 50:39 - 42). A more recent randomised trial, (Tjioe et al. Acta Derm Venereol 2002; 82:369-372)of 28 patients treated with narrow band UVB for a year showed no added benefit of adding supplementary vitamin B12 and folic acid to the treatment. Another study (Julin L, Olsson MJ. Acta DermVenereol 1997;77;50:39-42) using these two vitamins with solar UV exposure showed an improvement, but the UV exposure was not standardised and there was no control group.
Para amino benzoic acid (PABA)
This is one of the components of folic acid which probably accounts for its apparent effect on vitiligo. It is an ingredient of some sunscreens as it can block some UV light. Although it has been reported to promote repigmentation, this is only in combination with other B complex vitamins. It has been reported to cause vitiligo in one case. (J Am. Academ Dermatol. 1983; 9:770}
Phenylalanine
Phenylalanine is an essential amino acid which is found in a normal diet. It may increase the body's tolerance to UVA. There are a few reports of some improvements in patients having UVA treatment when phenylalanine is added. This has improved outcomes and it is suggested that this warrants more investigation. ( Szczurko O. and Boon HS. A Systematic Review of Natural Health product treatment for vitiligo. BMC Dermatology 2008 8:2 – online publication)
Beta carotene
This is a precursor of vitamin A. In large doses it is deposited in the skin giving it a yellow tint. Some people have used this to colour the very white patches of vitiligo. It does not remain in the skin, so would need to be taken continuously to maintain the colour. In normal amounts in food it has a protective effect against damage by free radicals. Free radicals are toxic waste products produced as a result of a biochemical process in the body. They cause damage to tissue cells and are believed to be implicated in many chronic diseases.
Vitamin D
Vitamin D is only found in a few foods such as oily fish, cod liver oil, liver, milk, eggs and foods such as margarine, some milk powders and yogurts and some cereals are fortified with it in the UK. It is vital for bone health and can help to maintain a healthy immune system. About 90% of the requirement of vitamin D is synthesised by the body from the effect of UVB rays on the skin. There has been concern that in people with vitiligo continuous use of sunblock may prevent the body producing the vitamin itself. Most of the vitamin D is formed during the summer and only a small amount of exposure (15 – 20 minutes a day two or three times a week) will provide sufficient as well as body stores for the winter months when sunlight levels are lower. It is best to spread the exposure over the week. There is some debate about how much sun vitiligo patients should have as some is thought to be beneficial (Ref Dispatches No 32 page 8 July 2003)
Minerals
Copper, iron, zinc and calcium all have a role in the pigmentation process. Low levels of zinc and copper have been linked with premature greying hair. Low levels of both minerals have also been found in de-pigmented skin. Iron is also low in de-pigmented skin and has a role in the activation of tyrosinase. Tyrosinase is a copper requiring enzyme and is essential in the pigmentation process.
Antioxidants
Recent research has shown the importance of preventing tissue damage by free radicals. It is thought that a good supply of antioxidant nutrients can improve the immune system function and help prevent chronic diseases, such as heart disease and some cancers. Antioxidants neutralise these free radicals and protect against the damage. This is increasingly seen as an important factor in vitiligo too. The main antioxidant nutrients are vitamins A. C. E. carotene and folic acid, polyphenolic flavanoids and some minerals such as selenium, copper and zinc. Though selenium levels in the British diet have fallen in recent years a study showed that blood levels in vitiligo patients were not low. A recent randomised controlled trial (Dell’Anna et al. Clinical and Experimental Dearmatology, 32,631-636) showed that giving antioxidants with narrowband UVB improved the effectiveness of the light treatment.
Curcumin, (Turmeric)
In the diet has been shown to be reduce the effectiveness of treatment of vitiligo with pseudocatalase in a small study of asian patients who have a significant amount of turmeric in their diet.(Schallreuter K. Rokos.H. Indian J. Dermatol, Venreol, Leprol 72: 57-59)
Summary
It is clear that there is no simple nutritional answer to vitiligo. However, as a good supply of nutrients is required both to promote a healthy skin and in the pigmentation process, a good, varied diet is important.
The best way to ensure adequate amounts of these nutrients is by having as much variety as possible in the diet including plenty of fruit and vegetables (at least five servings per day). A variety of starchy foods as a basis for each meal and smaller servings of fat rich and highly processed foods is recommended. It is better to try and increase the nutrient rich foods in the diet than rely on too many supplements. Although supplements can have a place sometimes, there may still be unknown beneficial factors available in foods that are not provided by nutrients in tablet form.
食品，当然是一个领域，感觉可能给我们的生活带来了一定的控制。操纵饮食，有时是有助于治疗湿疹样的一些条件。然而，在饮食中的戏剧性的变化可以导致其他问题，如果没有一定的知识或咨询。例如，在一些文化中，它已建议（没有证据），避免白色食物可导致白癜风的改善。这涉及到避免奶制品是钙的良好来源，特别是对年幼子女，谁需要它来开发强健骨骼和牙齿的重要。
人体是一个复杂的的机制，由数百万个细胞和复杂的激素和酶系统调节。广泛的营养需要保持在一个良性运转状态。不仅是营养物质需要，但他们自己互动，抑制，竞争或互相依赖的有效运作。这就是为什么挑选出一种维生素或矿物质单独作为一个问题的原因或采取作为补充通常不会有帮助。
有几种维生素和矿物质，参与生产的黑色素，在色素沉着过程中所涉及的酶。白癜风的过程中可能有一些效果，特别是对这些兴趣集中。如果是简单，只要找到一个故障营养，我们就会有一个治愈不久前。因为白癜风可以提高自发的，它有时被假设，这是发生是由于别的东西如另一个条件或改变饮食治疗。这导致了报告，没有一个健全的科学依据，某些营养素可以治愈白癜风。这也导致了更多的研究，试图了解某些营养物质是如何参与皮肤色素沉着。这些研究迄今已难以进行，通常有少量的参与者，大多不是很可靠。可以，但是，他们帮助建立我们的饮食和白癜风之间的连接的整体理解
维生素B12和叶酸
在与恶性贫血患者，维生素B12是不是身体，因为在其吸收所需的胃的物质是不存在的。恶性贫血是与白癜风相关的自身免疫性疾病之一。有偶然的报告，在这两种疾病在同一病人存在的情况下，注射维生素B12的白癜风治疗恶性贫血时也提高了。蒙特斯指出白癜风，维生素B12水平低10.7％，在他们的血液在他的病人他的研究。这项工作是在阿根廷，来自英国的饮食是非常不同的。 （蒙特斯低频，白癜风，营养治疗; Westhoven出版社。
蒙特斯低频白癜风：目前的知识和营养疗法（第二版）Westhoven出版社，布宜诺斯艾利斯2006年
叶酸含有色素沉着过程中发挥的作用的物质。维生素B12和叶酸的工作紧密结合起来。二者都需要，以方便一些生物过程，并已进行调查，共同研究项目。一项小型研究（在所有15名学员），与维生素C这两种营养素显示一半的患者（蒙特斯等表皮1992年; 50:39 - 42）。一些重的色素沉着。最近的一个随机试验，（Tjioe等文献真皮Venereol 2002; 82:369-372）一年窄谱UVB治疗的28例患者均无添加补充维生素B12和叶酸治疗的额外的好处。 （Julin升，奥尔森MJ文献DermVenereol 1997年; 77; 50:39-42），使用这两种维生素暴露于太阳紫外线的另一项研究显示，一种进步，但紫外线照射不规范，没有对照组。
帕拉氨基苯甲酸（PABA）
这是叶酸的组成部分，这可能对白癜风有明显的效果之一。这是一些防晒霜的成分，因为它可以阻挡一些紫外线光。虽然据报道，以促进复色，这是只有在与其他复合维生素B相结合。据报道导致白癜风的一个案例。 （J Academ皮肤科杂志1983;。9:770}
苯丙氨酸
苯丙氨酸是一种必需氨基酸，发现这是一个正常的饮食。它可能会增加人体的耐受性的UVA。有一些改进添加苯丙氨酸时，在长波紫外线治疗的病人数报告。这更好的成果和建议，这是值得更多的调查。 （Szczurko O.和皇家协的天然保健品的治疗白癜风BMC皮肤科2008 8:2的系统评价 - 网上公布）
β-胡萝卜素
这是它是沉积在皮肤给它一个黄色的色调，大剂量维生素A的前体。有人曾用这颜色很白白癜风的补丁。它不留在皮肤上，因此需要不断保持颜色。在食品中的正常量，它有一个对自由基损伤的保护作用。自由基是有毒废物生产的产品在体内生化过程的结果。他们组织细胞造成损害的，被认为是许多慢性疾病有牵连。
维生素D
维生素D是只有在油性鱼类，鱼肝油，肝脏，牛奶，鸡蛋和食物，如人造黄油如一些食品中发现，一些奶粉和酸奶和一些谷物与它在英国的强化。这是对骨骼健康非常重要，可以帮助维持健康的免疫系统。 UVB射线对皮肤的影响，约90％是由人体合成维生素D的要求。有人担心，在白癜风连续使用防晒霜的人可以阻止人体产生维生素本身。大多数维生素D的形成在暑假期间，只有少量的接触（15 - 20分钟，每天一个星期两次或三次）将提供足够以及身体储存冬季的几个月的阳光水平较低时。这是最好的传播比上周曝光。太阳白癜风患者应该有一些被认为是有益的多少有一些辩论（编号调度否32页2003年7月8日）
矿产
铜，铁，锌，钙都在色素沉着过程中的作用。已过早花白的头发与水平低的锌和铜。水平低的两种矿物质也被发现在去皮肤色素。铁也很低，去皮肤色素，并已在酪氨酸酶的激活的作用。酪氨酸酶是铜酶和色素沉着过程中至关重要。
抗氧化剂
最近的研究表明，防止组织损伤自由基的重要性。它被认为是良好的抗氧化营养素供给可以提高免疫系统的功能，有助于预防慢性疾病，如心脏疾病和某些癌症。抗氧化剂中和这些自由基和防止损害。这是越来越被看作是一个重要因素，在白癜风。主要的抗氧化营养素是维生素ACE胡萝卜素和叶酸，多酚类黄酮类化合物和一些矿物质，如硒，铜和锌。尽管英国饮食中的硒含量下降近年来的一项研究表明，白癜风患者的血药浓度不低。最近的一项随机对照试验（Dell'Anna等临床和实验Dearmatology，32,631-636）显示，提供窄带UVB的抗氧化剂，提高光治疗的有效性。
姜黄素（姜黄）
在饮食上已被证明是减少一个小型研究亚洲患者，在他们的饮食有一个显著郁金pseudocatalase治疗白癜风的有效性。（H ·印度研究光Schallreuter Rokos。皮肤科，Venreol Leprol 72：57-59）
摘要
很清楚，有没有简单的答案白癜风的营养。然而，作为一个良好的养分供应是既要促进健康的皮肤色素沉着过程中，一个很好的，多样化的饮食是很重要的。
确保这些营养素的足够数量的最好方法是尽可能在尽可能多的各种饮食，包括大量的水果和蔬菜（每天至少5份）。各种淀粉类食物作为每餐的基础和富含脂肪和高度加工食品小份建议。这是更好地尝试和增加营养丰富的食物，在饮食上比依赖太多补充剂。虽然补充剂可以有一个地方，有时，也有可能仍然是未知的有利因素可在不提供营养片剂形式的食物。
相关文章
[错误报告] [推荐] [收藏] [打印] [关闭] [返回顶部]
已有
